Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia☆☆☆
نویسندگان
چکیده
BACKGROUND In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. RESULTS Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. CONCLUSIONS No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.
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